Risks of Testosterone Replacement Therapy in Men (TRT)
Testosterone is a hormone produced primarily in the testicles in men and in smaller amounts in the ovaries in women. Testosterone levels are significantly higher in males and increase during puberty, then gradually decline around age 30. In addition, the adrenal glands produce dehydroepiandrosterone (DHEA), which the body can convert into testosterone and estrogen.
Testosterone plays a key role in male health, including libido, sperm production, muscle mass, bone density, and fat distribution. Synthetic testosterone (anabolic steroids) may be delivered through injections, gels, or patches.
Symptoms Associated With Low Testosterone
Low testosterone levels may be associated with:
- Decreased libido
- Erectile dysfunction
- Low energy and fatigue
- Weight gain
- Depression
- Mood changes or instability
- Decreased body hair
- Loss of muscle mass
- Decreased bone density (osteoporosis risk)
Testosterone Replacement Therapy (TRT) and Overuse Concerns
In recent years, “low T” advertising and testosterone replacement therapy have become more common. However, overuse or unnecessary use of testosterone therapy can create health risks.
Some individuals, including athletes and bodybuilders, misuse synthetic testosterone at high doses for performance or appearance enhancement. In addition, some clinics prescribe testosterone without fully evaluating underlying causes of symptoms such as fatigue or low libido.
Research suggests that true testosterone deficiency (based on diagnostic criteria) occurs in a relatively small percentage of men:
- 0.1% of men in their 40s
- 0.6% of men in their 50s
- 3.2% of men in their 60s
- 5.1% of men in their 70s
Potential Risks of High or Long-Term Testosterone Use
High-dose or long-term testosterone therapy may increase the risk of:
- Acne
- Increased red blood cell count
- Sleep disturbances
- Mood changes, hostility, or aggression
- Liver or kidney strain
- Male infertility
- Breast tenderness
- Increased risk of male breast tissue changes
- Potential increased risk of prostate-related concerns
- Cardiovascular events (heart attack, stroke, heart failure)
Important Health Considerations Before Starting TRT
Before starting testosterone therapy, it is important to evaluate overall health and possible contributing factors, including:
- Diet and nutrition
- Exercise habits
- Sleep quality
- Stress levels
- Relationship or psychological factors
- Cardiovascular health (which may affect erectile dysfunction)
Low testosterone symptoms may overlap with other conditions, so proper evaluation is important before treatment begins.
Testing and Monitoring Testosterone Therapy
When testosterone therapy is considered, baseline and ongoing lab testing is important. A basic complete blood count (CBC) alone is not sufficient in many cases.
At Alta Mountain Chiropractic, we emphasize a more complete approach to monitoring, which may include:
- CBC (complete blood count)
- Metabolic panel
- Thyroid panel
- Cholesterol/lipid panel
- Sex hormone panel
- Inflammation markers
- Iron levels
Ongoing monitoring helps evaluate overall health changes during treatment.
Testosterone, Inflammation, and Lifestyle Factors
Inflammation plays an important role in hormone balance. Elevated inflammatory markers (such as C-reactive protein, TNF-alpha, and other cytokines) often correlate with lower testosterone levels.
At the same time, research and clinical observation continue to evaluate whether low testosterone contributes to inflammation or whether inflammation drives lower testosterone levels. Lifestyle factors often play a central role in both.
Common Factors That May Lower Testosterone Production
Several factors can reduce natural testosterone production:
1. Chronic stress (cortisol)
Increased stress raises cortisol, which can interfere with hormone production, including testosterone and DHEA.
2. Insulin resistance
Higher insulin levels are often associated with lower testosterone levels. This can create a cycle involving weight gain and metabolic dysfunction.
3. Excess body fat (adipose tissue)
Excess adipose tissue increases inflammation and aromatase activity, which can increase estrogen and reduce testosterone.
4. Mitochondrial dysfunction
Cellular energy dysfunction may affect hormone-producing cells. Contributing factors include poor diet, smoking, alcohol use, sleep disruption, and exposure to processed foods and environmental toxins.
Natural Ways to Support Healthy Testosterone Levels
In many cases, testosterone levels may improve with lifestyle changes such as:
- Reducing systemic inflammation
- Regular exercise, including resistance training
- Getting 7+ hours of quality sleep
- Eating whole foods and lean protein sources
- Supporting zinc, magnesium, and vitamin D intake
- Supporting adrenal health
- Reducing alcohol intake
- Managing stress effectively
- Avoiding endocrine-disrupting chemicals when possible
- Limiting ultra-processed foods
TRT: When It May Be Appropriate
Testosterone replacement therapy may be appropriate in select cases when clinically indicated. However, long-term use may reduce the body’s natural ability to produce testosterone.
For this reason, it is important to evaluate underlying causes before starting therapy and consider whether lifestyle and metabolic factors may be contributing.
Low Testosterone Evaluation in Sandy, Utah
At Alta Mountain Chiropractic, we evaluate hormone health in the context of overall metabolic, inflammatory, and lifestyle factors. When appropriate, we may recommend laboratory testing and individualized treatment planning.
If you are concerned about low testosterone or “low T” symptoms, contact Alta Mountain Chiropractic at 801-523-2582 to schedule a consultation with Dr. Nathan Eldredge.


